Top 25 Best Alternative Polyadenylation Sites

Alternative Polyadenylation Sites

What is alternative polyadenylation?

Alternative polyadenylation (APA), a phenomenon that RNA molecules with different 3′ ends originate from distinct polyadenylation sites of a single gene, is emerging as a mechanism widely used to regulate gene expression.

Where are alternative polyadenylation pa sites located?

APA, alternative polyadenylation. Alternative pA sites in mouse and human genome have been shown to be located mainly in 3′UTRs (UTR-APA) [35], which often harbor various regulatory sequences.

What is alternative cleavage and polyadenylation (APA)?

Alternative cleavage and polyadenylation (APA) thus gives rise to isoforms that differ either in their coding sequence (CDS) or in their 3ʹ UTRs. Fig. 1: Overview of core 3ʹ end processing factors and their interaction elements in RNAs.

Can a gene have more than one polyadenylation site?

Many protein-coding genes have more than one polyadenylation site, so a gene can code for several mRNAs that differ in their 3′ end. The 3’ region of a transcript contains many polyadenylation signals (PAS).

Alternative Polyadenylation Sites

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