Best 25 Alternative Translation Start Sites
Alternative Translation Start Sites
UORFs, Reinitiation And Alternative Translation Start Sites In Hum…
Alternative translation start sites and hidden coding
Alternative Translation Start Sites And Hidden Coding …
Alternative translation start sites and hidden coding
Alternative Translation Start Sites Are Conserved In …
Alternative translation start sites and hidden coding
[Alternative Translation Start Sites And Their Significance For ...
Alternative translation start sites and hidden coding
Alternative Translation Start Sites Are Conserved In …
Abstract. It is widely suggested that a eukaryotic mRNA typically contains one translation start site and encodes a single functional protein product. However, according to current points of view on translation initiation mechanisms, eukaryotic ribosomes can recognize several alternative translation start sites and the number of experimentally verified examples of alternative …
Alternative Translation Start Sites And Hidden Coding …
Alternative translation start sites are conserved in eukaryotic genomes. Alternative start AUG codons within a single transcript can contribute to diversity of the proteome; however, their functional significance remains controversial. Here, we provide comparative genomics evidence that alternative start codons are under negative selection in vertebrates, insects and yea ….
UORFs, Reinitiation And Alternative Translation Start Sites In …
Current models of translation initiation and contextual organization of eukaryotic mRNA leader region are reviewed. Hypothesis on frequent usage of several alternative start codons is discussed. Potential contribution of alternative translation start sites to eukaryotic mRNA coding potential is cons …
Major Egr3 Isoforms Are Generated Via Alternate …
Alternative start AUG codons within a single transcript can contribute to diversity of the proteome; however, their functional significance remains controversial. Here, we provide comparative genomics evidence that alternative start codons are under negative ...
UORFs, Reinitiation And Alternative Translation Start Sites In …
start codon of 50-end extended CDS version (uORF3). If the start codon of CDS is located in a suboptimal context, translation can be initiated at downstream AUGs by the leaky Figure 2. Alternative translation start sites and variants of alternative open reading frames within eukaryotic mRNA. uORFs start from AUG codons located within 50-untranslated
Alternative Translation And Retrotranslocation Of Cytosolic …
Apr 16, 2008 · Statistical analysis supported the hypothesis on reinitiation of translation at downstream AUG codons and functional significance of potential alternative ORFs. It may be assumed that some 5'UTR-located upstream ORFs can deliver ribosomes to alternative translation starts, and they should be taken into consideration in the prediction of human ...
Alternative Translation Start Sites And Hidden Coding …
Either proteolytic cleavage of full-length Egr3 or utilization of an alternative translation start site could yield a truncated Egr3 isoform with an N terminus located just prior to or within the internal segment targeted by αEgr3-INT (amino acids 101 to 189). However, we favored the latter alternative since we reliably obtain the shorter ...
Alternative Translation Start Sites And Their Significance For ...
Apr 16, 2008 · It has been proposed earlier that many eukaryotic mRNAs contain alternative translation start sites either upstream or downstream of annotated TIS, and the proteins encoded can be synthesized as isoforms with different N-end segments.
Alternative Translation Start Sites And Their Significance For ...
May 11, 2022 · The use of alternative translational start sites allows a large number of eukaryotic proteins to be produced from the surprisingly few number of genes due found in the human genome , and is a recognized mechanism for controlling production of alternative protein isoforms with altered function or subcellular localization.
Alternative Translation Initiation Generates A ... - ScienceDirect
It is widely suggested that a eukaryotic mRNA typically contains one translation start site and encodes a single functional protein product. However, according to current points of …
Putative Alternative Translation Start Site-encoding Nucleotides Of ...
Up to 10% cash back · The review is dedicated to the current notions of translation initiation and the contextual organization of eukaryotic mRNA leader regions. A hypothesis on the frequent usage of several alternative start codons is discussed. A potential contribution of alternative translation start sites to the coding potential of eukaryotic mRNAs is considered.
Alternative Translation Start Sites And Their Significance For ...
A potential contribution of alternative translation start sites to the coding potential of eukaryotic mRNAs is considered. The review is dedicated to the current notions of translation initiation and the contextual organization of eukaryotic mRNA leader regions and a hypothesis on the frequent usage of several alternative start codons is discussed.
Putative Alternative Translation Start Site-encoding Nucleotides Of ...
Jun 04, 2019 · This isoform is constitutively translated from an alternative CUG translation initiation start site located in the 5′ UTR of its mRNA. The RNA helicase eIF4A1 is needed to ensure translation of the long and the known short isoforms of MK2, of which the molecular properties were determined.
The Role Of Alternative Translation Start Sites In The Generation Of ...
Indeed, in silico analysis of the CPR5 transcript identified potential RNA secondary structures nearby putative alternative translation start sites and similar secondary structures have been shown to be important for the activity of alternative translation start sites [45–49]. Alternatively, or in addition, the induced mutations may have ...
Alternative Translation Start Sites Are Conserved In Eukaryotic …
Jan 10, 2006 · Download Citation | Alternative translation start sites and their significance for eukaryotic proteome | The review is dedicated to the current notions of translation initiation and the contextual ...
Alternative Translation Start Sites And Hidden Coding Potential Of ...
Jun 29, 2020 · Results: Our in silico studies suggest that in addition to three clusters of putative nuclear localization signals and four or five transmembrane domains, CPR5 contains two putative alternative translation start sites. To test the role of the methionine-encoding nucleotides implicated in those sites, metCPR5 cDNAs, in which the relevant nucleotides were changed to …
Alternative Translation Start Sites And Their Significance For ...
Jun 15, 2005 · Up to 10% cash back · According to the scanning model, 40S ribosomal subunits initiate translation at the first (5′ proximal) AUG codon they encounter. However, if the first AUG is in a suboptimal context, it may not be recognized, and translation can then initiate at downstream AUG(s). In this way, a single RNA can produce several variant products. Earlier …
Alternative Translation Start Sites Are Conserved In Eukaryotic …
The multiplicity of functional protein isoforms emerges due to alternative splicing, alternative promoters or alternative translation start sites. The first two mechanisms are major sources of proteome diversity in higher eukaryotes ( 1–4 ), and may contribute to the development of complex organisms from genomes carrying only a few tens of thousand of protein-coding genes.
Alternative Translation Start Sites Are Conserved In Eukaryotic …
It is widely suggested that a eukaryotic mRNA typically contains one translation start site and encodes a single functional protein product. However, according to current points of view on translation initiation mechanisms, eukaryotic ribosomes can recognize several alternative translation start sites and the number of experimentally verified examples of alternative …
Alternative Translation Start Sites Are Conserved In Eukaryotic …
Nov 30, 2005 · Download Citation | Alternative translation start sites and their significance for eukaryotic proteome | Current models of translation initiation and contextual organization of eukaryotic mRNA ...