Best 25 Alternative Transcriptional Start Sites

Alternative Transcriptional Start Sites

What do we know about alternative transcription start sites?

1 Department of Molecular Medicine, Aarhus University Hospital, Skejby, 8200 Aarhus N, Denmark. Background: Approximately half of all human genes use alternative transcription start sites (TSSs) to control mRNA levels and broaden the transcriptional output in healthy tissues.

Is there only one optimal transcription start site for each gene?

Nevertheless, it is also possible that each gene has only one optimal transcription start site and that alternative transcriptional initiation arises primarily from molecular errors that are slightly deleterious.

What is Alternative transcriptional initiation (ATI)?

The transcription of a gene may start from one of several TSSs, a phenomenon known as alternative transcriptional initiation (ATI); the different core promoters used are referred to as alternative promoters [ 8, 9 ]. It has been reported that ATI occurs to most eukaryotic protein-coding genes [ 6, 7, 10 – 12 ].

What is the difference between a transcription start site and promoter?

The transcription start site (TSS) is the first nucleotide transcribed in a run of transcription, while the surrounding genomic region of the TSS is often referred to as the core promoter [ 1 ]. Owing to the strong association between TSSs and core promoters, these terms are sometimes used interchangeably [ 1 ].

Alternative Transcriptional Start Sites

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