Best 25 Alternative Splicing Alternate Donor And Acceptor Sites

Alternative Splicing Alternate Donor And Acceptor Sites

What is the alternative acceptor site for splicing?

Alternative acceptor site: An alternative 3' splice junction (acceptor site) is used, changing the 5' boundary of the downstream exon. Intron retention: A sequence may be spliced out as an intron or simply retained. This is distinguished from exon skipping because the retained sequence is not flanked by introns.

How is alternative splicing predicted in ASSP?

Splice site prediction. ASSP predicts putative alternative exon isoform, cryptic, and constitutive splice sites of internal (coding) exons. Skipped splice sites are not differentiated from constitutive sites. Non-canonical splice sites are not detected. Alternative splicing is predicted based on the DNA/RNA sequence information only.

How is alternative splicing of mRNA regulated?

Alternative splicing. The production of alternatively spliced mRNAs is regulated by a system of trans-acting proteins that bind to cis-acting sites on the primary transcript itself. Such proteins include splicing activators that promote the usage of a particular splice site, and splicing repressors that reduce the usage of a particular site.

How does competition between alternative splice sites arise?

Choice of alternative splice sites is made early in the assembly of the spliceosome complex. Competition between alternative sites depends on the relative quality of the constitutive splice signals, a balance that presumably can be shifted by protein factors acting on regulatory sequences ( 19 ).

Alternative Splicing Alternate Donor And Acceptor Sites

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